Manolis Kellis is a Professor of Computer Science and Computational Biology at MIT, a member of the Broad Institute, and head of the MIT Computational Biology Group.

Born in Greece, he moved to France at age 12 and came to the U.S. in 1993, earning his PhD from MIT where he received the Sprowls Award for best doctoral thesis in Computer Science.

Kellis has authored 250 journal publications cited 190,000 times and received the US Presidential Early Career Award (PECASE), NSF CAREER award, Sloan Fellowship, Gregor Mendel Medal, and was named Technology Review's Top 35 Innovators Under 35.

He co-led the NIH Roadmap Epigenomics Project, ENCODE, GTEx, and modENCODE projects to map the human epigenome and characterize genes and regulatory elements. He is also Co-Founder and Advisor at Secure AI Labs and associated with Mantis AI.

His lab's groundbreaking research on Alzheimer's disease, obesity genetics, and single-cell genomics has transformed understanding of disease mechanisms, with 2.3 million single-cell RNA profiles analyzed across 427 post-mortem human brain samples.